Highly purified polynucleotides
PN is made from DNA molecules extracted from Italian trout using patented Highly Purified Technology (HPT).
Polynucleotide skin booster · Singapore
PN injections: trout DNA to revitalise skin and tired eyes.
PN (polynucleotide) is an injectable skin booster made from DNA molecules extracted from Italian trout with patented Highly Purified Technology (HPT), to revitalise and repair damaged skin.
What is a PN injection?
Polynucleotides, the building blocks for skin repair.
A PN injection delivers polynucleotides from Italian trout DNA, purified with patented Highly Purified Technology (HPT), into the skin. The polynucleotides act as building blocks that encourage skin cells to produce more collagen and elastin, helping to repair damaged skin and improve firmness, elasticity and hydration.
PN encourages bio-revitalisation to reverse the signs of ageing, and regenerates fibroblasts and collagen to repair damaged skin. It is clinically proven to improve overall skin health from deep within the dermal layer, where collagen and elastin keep skin firm, elastic and youthful-looking.
Together, the polynucleotides and hyaluronic acid help improve overall hydration and skin elasticity and boost skin rejuvenation, for smooth, radiant skin.
PN and our PDRN injectable (salmon DNA fragments) are related but not interchangeable; your doctor will explain which suits your skin.
- Trout-derived — polynucleotides purified with HPT
- Collagen & elastin — building blocks for firmer, more elastic skin
- Face to scalp — from the eye area to the hands and scalp
- Minimal downtime — return to daily activities after treatment
How it works
How do PN injections work?
PN polynucleotides act as building blocks in the dermis, encouraging your skin cells to produce more collagen and elastin, the proteins behind firmness and elasticity. With hyaluronic acid, they also help improve hydration, while regenerating fibroblasts and collagen to help repair damaged skin.
Building blocks for firmer skin
Polynucleotides encourage your skin cells to produce more collagen and elastin, regenerating fibroblasts and collagen to repair damaged skin.
- Promotes skin firming and tightening
- Reduces fine lines and wrinkles
- Improves skin laxity, texture, tone and radiance
Hydration and skin barrier
With hyaluronic acid, PN helps boost hydration and elasticity and restore the skin barrier naturally.
- Boosts skin hydration and elasticity
- Restores skin barrier naturally
- Treats dull, dry and sensitive skin as well as enlarged pores
Tired eyes and dark circles
PN is also used around the eyes to revive tired eyes and reduce dark eye circles. Dark circles can have several causes, so your doctor first assesses what is behind yours.
Personalised assessment
What is PN used for?
PN is used for skin firmness, hydration and texture, acne scars and the delicate eye area. It is suitable for all skin types, but your doctor will discuss your concerns first so that the appropriate combination of treatments is chosen.
Fish allergy, pregnancy or a skin infection? Tell your doctor first.
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Firmness & fine lines
Promotes skin firming and tightening, reduces fine lines and wrinkles, and improves skin laxity.
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Hydration, texture & tone
Boosts hydration and elasticity, restores the skin barrier naturally, and improves texture, tone and radiance.
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Dull, dry & sensitive skin
For skin that looks dull, feels dry or sensitive, or has enlarged pores.
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Acne scars
Improves acne scars by regenerating fibroblasts and collagen to help repair damaged skin.
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Tired eyes & dark circles
Revives tired eyes and reduces dark eye circles, once the cause of your dark circles has been assessed.
Your treatment journey
Doctor consultation. Numbing first. A planned course.
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Consult
Each patient is unique, so a consultation with one of our doctors comes before treatment, to agree the areas and any combination treatments.
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Prepare
Topical anaesthesia is applied to minimise any discomfort.
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Treat
The PN injectable is administered into your skin. The whole treatment takes around 45 minutes, including numbing.
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Recover
Mild swelling or redness over the injection sites is temporary, and you can return to daily activities. Sessions are usually 3–4 weeks apart.
From our clinic
What causes dark circles, and can PN help?
Dark circles and under-eye bags rarely have one cause: pigmentation, thin skin, volume loss and tear troughs each need a different approach. In this reel, our team explains why we assess the cause first. PN is one of the options used for tired eyes and dark circles.
Safety & expectations
Every patient is unique: a doctor’s consultation comes before any PN injection.
There may be mild, temporary swelling or redness at the injection sites. Tell your doctor about any fish allergy, medicines, skin conditions or recent treatments, especially before treatment around the eyes.
PN Injectable (Trout DNA): frequently asked questions
What are polynucleotides?
Polynucleotides (PN) are chains of nucleotides, the units that make up DNA. In our PN injectable they come from DNA molecules extracted from Italian trout using patented Highly Purified Technology (HPT). Injected into the skin, they act as building blocks, encouraging skin cells to produce more collagen and elastin.
Can PN injections help dark circles and tired eyes?
PN injections are used to revive tired eyes and reduce dark eye circles, and the eyes are one of the treatment areas. Dark circles can come from pigmentation, thin skin, volume loss or tear troughs, so your doctor first assesses the cause and may combine PN with other treatments.
Can PN improve acne scars?
PN is used to improve acne scars. By regenerating fibroblasts and collagen, it helps repair damaged skin and improve texture, and it can also treat enlarged pores. Your doctor will assess your scars and may suggest combining PN with other treatments.
How many PN injection sessions will I need?
Usually 3 PN injection sessions are recommended, 3–4 weeks apart, to achieve desirable results. However, each patient is unique, and a consultation with one of our doctors is needed before treatment to confirm your plan.
What can I expect during and after a PN injection?
Topical anaesthesia is applied first to minimise discomfort, and the PN injectable is then administered into your skin; allow around 45 minutes in total, including numbing time. Downtime is minimal: any swelling or redness at the injection sites is usually mild and passes, so most people return to their daily activities after treatment.
Can PN be combined with other treatments?
Yes. A multi-layer approach often yields better results. You can discuss with our doctors which treatment options suit your needs, and they will recommend an appropriate combination of PN and other treatments for your skin.
Is a PN injection the same as PDRN?
No. PN and PDRN are both DNA-derived, but they are different products. A PN injection uses polynucleotides from Italian trout DNA, purified with patented Highly Purified Technology (HPT), and is also used around the eyes. Our PDRN injectable uses salmon DNA fragments; its page compares the two in more detail.
Who should not have PN injections?
Because PN comes from trout DNA, let your doctor know about any fish allergy. If you are pregnant or breastfeeding, or have an active skin infection where PN would be injected, treatment may be postponed. Tell your doctor about your medicines and previous injections too, especially if the eye area is being treated.
Doctor-led care
Assessed and planned by our doctors.
Appointments
Ready to find out what PN can do for your skin?
Book a consultation today. Our doctors will assess your skin and plan the treatment areas and combination that suit you.